Charitable foundations play a critical role in improving the quality of life for the less fortunate. Established and funded by corporations or individuals, these philanthropic organisations work tirelessly to address pressing global challenges through their charitable initiatives. Let's take a look at the world's wealthiest charitable foundations.
Experience a new level of financial clarity and control of your family office. Altoo Wealth Platform!

Novo Nordisk Foundation, Denmark

August Krogh, a Nobel laureate, established the Novo Nordisk Foundation in 1922 as a prime example of a foundation with a focus on social causes and scientific innovation. In addition to supporting scientific progress, humanitarian efforts, and social causes, the Foundation also invests in companies dedicated to improving health, promoting sustainability, and fighting disease. Novo Nordisk, Denmark’s largest pharmaceutical company, produces and sells insulin to treat diabetes. The foundation’s endowment, valued at approximately $70.8 billion as of December 2021, has made it one of the world’s wealthiest charitable foundations.

Bill and Melinda Gates Foundation, United States

Established in 2000, the Bill & Melinda Gates Foundation is known for its philanthropic work to fight poverty, disease, and injustice in the developing world. With an endowment of nearly $55.1 billion, the foundation works to improve global health, education, and access to technology. The foundation receives funding from renowned investor Warren Buffett in addition to a sizeable donation of $20 billion in Microsoft stock from its founders. Through partnerships with the public and private sectors, the foundation has made significant progress in areas such as health care, immunisation, and poverty alleviation.

Howard Hughes Medical Institute, United States

Founded in the late 1940s by aviator and industrialist Howard Hughes, the Howard Hughes Medical Institute (HHMI) is dedicated to advancing biomedical research and education. With a consolidated net asset value of approximately $27.1 billion, HHMI supports ground-breaking scientific discoveries and fosters a more inclusive scientific community. Through its funding, the Institute enables scientists and students to contribute to advances in genetics, neuroscience, and other fields. HHMI’s international programmes impact developing countries and advance knowledge and research in the basic sciences.

Wellcome Trust, United Kingdom

Founded in 1936 by pharmaceutical entrepreneur Sir Henry Wellcome, the Wellcome Trust is committed to using the power of science to improve global health and well-being. With an investment portfolio of approximately $46.4 billion, the Trust funds research institutes and individual researchers around the world. It believes in collaborative scientific research across health science disciplines as the key to a healthier, happier world. The Wellcome Trust focuses on tackling major health issues, including mental health, infectious diseases, and climate change. By partnering with researchers and institutions, the Trust drives advances in medicine and promotes a deeper understanding of health challenges. 

Your Wealth, Our Priority: Altoo's Consolidation Power, Secure Document Management, and Seamless Stakeholder Sharing for High Net Worth Individuals. Preview Platform.

Learn More about Foundations

We think you might like

How do you run an effective family office when the family's patriarch is in Geneva and his adult children live in London and New York? According to Campden Wealth research, for more than half of family offices this kind of question isn't hypothetical: They serve at least one family member residing outside the family office's primary jurisdiction. The coordination challenge this creates isn't just logistical. It's structural, and it demands infrastructure built for distributed operations from the start.
In 2025, an estimated 142,000 millionaires will relocate internationally, according to Henley & Partners' latest private wealth migration report. The UK alone faces a net outflow of 16,500 wealthy individuals — the largest exodus any country has experienced since tracking began. Dubai, Switzerland, and Singapore welcome thousands more each year. The Great Wealth Migration, as some call it, is well underway. The result is greater physical mobility without greater asset consolidation. Technology to consolidate the data around diverse assets can bridge the gap.
Trade disputes, sanctions and capital controls can reorder markets in a single news cycle. When they do, risk management stops being abstract. It becomes concrete and personal: where an asset is custodied, which passport a principal travels on, the jurisdiction an entity sits in, and whether the documents you need to act are ready. If wealth is spread across banks, vaults, partnerships and family members in multiple countries, exposure is spread too.

In case you missed it

For many family offices, the risks are no longer theoretical. Governance is informal, reporting delayed, and portfolios are growing more complex by the quarter. Yet many still rely on basic spreadsheets to track billions. According to Copia Wealth, citing KPMG data from 2025, more than 57% of global family offices continue to use general tools like Excel for core financial reporting.
Altoo: The Gateway to Secured Streamlined Wealth for Your Family Office. Discover Altoo

Resource Center

Popular Articles

Featured Today

About Altoo

Insights On Wealth Management And More.

Delivered To Your Inbox.
Left Menu Icon