Charitable foundations play a critical role in improving the quality of life for the less fortunate. Established and funded by corporations or individuals, these philanthropic organisations work tirelessly to address pressing global challenges through their charitable initiatives. Let's take a look at the world's wealthiest charitable foundations.
Simplify Complex Wealth Management: Explore Altoo's Premium Features. Preview Altoo Wealth Platform.

Novo Nordisk Foundation, Denmark

August Krogh, a Nobel laureate, established the Novo Nordisk Foundation in 1922 as a prime example of a foundation with a focus on social causes and scientific innovation. In addition to supporting scientific progress, humanitarian efforts, and social causes, the Foundation also invests in companies dedicated to improving health, promoting sustainability, and fighting disease. Novo Nordisk, Denmark’s largest pharmaceutical company, produces and sells insulin to treat diabetes. The foundation’s endowment, valued at approximately $70.8 billion as of December 2021, has made it one of the world’s wealthiest charitable foundations.

Bill and Melinda Gates Foundation, United States

Established in 2000, the Bill & Melinda Gates Foundation is known for its philanthropic work to fight poverty, disease, and injustice in the developing world. With an endowment of nearly $55.1 billion, the foundation works to improve global health, education, and access to technology. The foundation receives funding from renowned investor Warren Buffett in addition to a sizeable donation of $20 billion in Microsoft stock from its founders. Through partnerships with the public and private sectors, the foundation has made significant progress in areas such as health care, immunisation, and poverty alleviation.

Howard Hughes Medical Institute, United States

Founded in the late 1940s by aviator and industrialist Howard Hughes, the Howard Hughes Medical Institute (HHMI) is dedicated to advancing biomedical research and education. With a consolidated net asset value of approximately $27.1 billion, HHMI supports ground-breaking scientific discoveries and fosters a more inclusive scientific community. Through its funding, the Institute enables scientists and students to contribute to advances in genetics, neuroscience, and other fields. HHMI’s international programmes impact developing countries and advance knowledge and research in the basic sciences.

Wellcome Trust, United Kingdom

Founded in 1936 by pharmaceutical entrepreneur Sir Henry Wellcome, the Wellcome Trust is committed to using the power of science to improve global health and well-being. With an investment portfolio of approximately $46.4 billion, the Trust funds research institutes and individual researchers around the world. It believes in collaborative scientific research across health science disciplines as the key to a healthier, happier world. The Wellcome Trust focuses on tackling major health issues, including mental health, infectious diseases, and climate change. By partnering with researchers and institutions, the Trust drives advances in medicine and promotes a deeper understanding of health challenges. 

Wealth Aggregation: Simple, Dynamic, and Secure Beyond Compare. Discover the Altoo Wealth Platform!

Learn More about Foundations

We think you might like

In 2025, an estimated 142,000 millionaires will relocate internationally, according to Henley & Partners' latest private wealth migration report. The UK alone faces a net outflow of 16,500 wealthy individuals — the largest exodus any country has experienced since tracking began. Dubai, Switzerland, and Singapore welcome thousands more each year. The Great Wealth Migration, as some call it, is well underway. The result is greater physical mobility without greater asset consolidation. Technology to consolidate the data around diverse assets can bridge the gap.
The political climate for sustainable finance has cooled in the United States. Donald Trump’s return to the White House has weakened support for environmental, social and governance (ESG) policies. Fund flows show that enthusiasm has faded among some institutional investors. However, the picture looks significantly different from the viewpoint of family offices. These private vehicles, which manage wealth for ultra-wealthy families, continue to persist in sustainable investing.
Family offices are rapidly expanding their service offerings, with family engagement and education emerging as the most frequently added service since 2023. Behind this trend lies a complex reality: successful family engagement requires moving beyond traditional educational approaches to embrace active participation, address learning needs that extend beyond finance, and navigate the challenges of globally dispersed families.

In case you missed it

For many family offices, the risks are no longer theoretical. Governance is informal, reporting delayed, and portfolios are growing more complex by the quarter. Yet many still rely on basic spreadsheets to track billions. According to Copia Wealth, citing KPMG data from 2025, more than 57% of global family offices continue to use general tools like Excel for core financial reporting.
Altoo: Secure Swiss Professional for Consolidated Assets and Document Management. Platform Preview.

Resource Center

Popular Articles

Featured Today

About Altoo

Insights On Wealth Management And More.

Delivered To Your Inbox.
Left Menu Icon